Volume 2, Issue 2

Original research papers

Pharmaceutcal Sciences


H. I. Harbatsevich, N. V. Loginova , K. A. Nabebina, S. I. Stakhevich, I. N. Slabko, N. P. Osipovich, G. A. Ksendzova, I. I. Azarko

Pages: 129-133

DOI: 10.21175/RadJ.2017.02.027

Received: 12 FEB 2017, Received revised: 1 MAY 2017, Accepted: 26 JUN 2017, Published online: 28 OCT 2017

The process of Ni(II) ion complexation with cycloaminomethyl derivatives of 1,2-dihydroxybenzene in a water-ethanol medium was investigated. It was found potentiometrically that the complexes with the ratio M : L = 1 : 2 were formed in the solution, their overall stability constants were equal to 7,9∙1014–1,6∙1015. The Ni(II) complexes synthesized were shown to be amorphous, neutral, and thermally stable up to 150 °C. Their coordination polyhedra have the composition [NiO2N2] and planar square geometry. It was shown that the Ni(II) complexes demonstrate a moderate or high level of antimicrobial activity against bacteria and fungi strains tested, as well as the ability to neutralize superoxide.
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