Volume 2, Issue 2

Original research papers

Radiation in Medicine

IRRADIATION ACTIVITY WITH THE TOP-IMPLART PROTON LINEAR ACCELERATOR

M. Vadrucci, A. Ampollini, F. Borgognoni, P. Nenzi, L. Picardi, C. Ronsivalle, V. Surrenti, E. Trinca

Pages: 101-107

DOI: 10.21175/RadJ.2017.02.022

Received: 15 FEB 2017, Received revised: 26 APR 2017, Accepted: 22 JUL 2017, Published online: 28 OCT 2017

A proton linear accelerator devoted to proton therapy application, is under construction in the “Particle Accelerators and Medical Applications Laboratory” at the ENEA Frascati research center in the framework of the TOP (Terapia Oncologica con Protoni) – IMPLART (Intensity Modulated Proton Linear Accelerator for RadioTherapy) project funded by the regional government of Lazio in Italy. The proton linac is composed by a modular sequence of RF linear accelerators designed to reach the energy of 150 MeV. The beam features, particularly useful for very conformal irradiation of tumours in complex anatomical regions, can be likewise translated to other situations. Therefore, during the process of commissioning of the TOP-IMPLART accelerator, the beam has been also made available as a versatile proton source for ancillary experiments in the framework of other projects. Presently, indeed, the maximum TOP-IMPLART beam energy is 35 MeV and this section delivers a 3 usec pulsed beam at the maximum repetition frequency of 25 Hz with a variable charge in each pulse in the range 5-100 pC. This beam is used for pilot experiments to simulate cosmic conditions on the ground and PIXE (Particle Induced X-ray Emission) analysis for the determination of elemental composition of archeological and old painting samples. This work presents an overview of these activities, describing in detail the different set up adopted to perform the tests and the main achieved results.
  1. Particle therapy facilities in operation, Particle Therapy Co-Operative Group, Villigen, Switzerland, 2017.
    Retrieved from: https://www.ptcog.ch/index.php/facilities-in-operation
    Retrieved on: Feb. 5, 2017
  2. G. Messina, U. Bizzarri, C. Ronsivalle et al., “The activity on accelerators at the ENEA Frascati Center:status and perspectives,” in Proc. I European Particle Accelerators Conference (EPAC88), Rome, Italy, 1988, pp. 1477 – 1479
    Retrieved from: http://accelconf.web.cern.ch/AccelConf/e88/PDF/EPAC1988_1477.PDF
    Retrieved on: Feb. 5, 2017
  3. L. Picardi, G. Messina, C. Ronsivalle, A. Vignati, “The activity on linear accelerators at the ENEA Frascati Center,” in Proc. 1992 Linear Accelerator Conference, Ottawa, Canada, 1992, pp. 510 – 512
    Retrieved from: http://accelconf.web.cern.ch/AccelConf/l92/papers/tu4-69.pdf
    Retrieved on: Feb. 5, 2017
  4. L. Picardi, C. Ronsivalle et al., “The italian IORT project,” in Proc. EPAC 2000 Conference, Vienna, Austria, 2000, pp. 2545 – 2547
    Retrieved from: http://accelconf.web.cern.ch/AccelConf/e00/PAPERS/WEP5B04.pdf
    Retrieved on: Feb. 5, 2017
  5. C. Ronsivalle et al., “The TOP-IMPLART Project,” Eur. Phys. J. Plus,vol. 126, no. 68, pp. 166 – 168, Jul. 2011.
    DOI: 10.1140/epjp/i2011-11068-x
  6. W. D. Kilpatric, “Criterion for Vacuum Sparking designed to include both rf and dc,” Rev. Sci. Instrum., vol. 28, no. 10, p. 824, 1957.
    DOI: 10.1063/1.1715731
  7. C. Ronsivalle et al., “The TOP-IMPLART linac: machine status and experimental activity,” in Proc. IPAC17, Copenhagen, Denmark, 2017, pp. 4669 – 4672
    Retrieved from: http://accelconf.web.cern.ch/AccelConf/ipac2017/papers/thpva090.pdf
    Retrieved on: Aug. 5, 2017
  8. M. Vadrucci et al., “First beam characterization of the TOP-IMPLART proton linear accelerator for cancer radiotherapy,” in Proc. 55th Annual Meeting for the PTCOG 2016, Prague, Czech Republic, 2016, pp. 201 – 202
    DOI: 10.14338/IJPT.16-PTCOG-1.1
  9. M. Vadrucci, P. Ferrari et al., “Preliminary characterization of the neutron field in TOP-IMPLART proton therapy facility,” in presented at the 56th Annual Meeting for the PTCOG, Kanagawa, Japan, 2017
    DOI: 10.14338/IJPT.17-PTCOG-1.1
  10. P. Ferrari, M. Vadrucci et al., “Preliminary study of neutron field in TOP-IMPLART proton therapy beam,” to be published in Proc. NEUDOS 2017, Kraków, Poland, 2017
  11. M. Vadrucci et al., “Analysis of Roman Imperial coins by combined PIXE, m-XRF and LIBS techniques,” Microchem. J., no. spec. issue, to be published.
  12. F. Novelli, M. Vadrucci et al., “Effects of in vivo proton irradiation on mouse spleen cells,” Radiation and Applications vol. 2, no. 3, to be published.
  13. M. Vadrucci et al., “A new small-footprint external-beam PIXE facility for cultural heritage applications using pulsed proton beams,” Nuclear Instruments and Methods in Physics B, to be published.
  14. M. Vadrucci et al., “The low-energy proton beam for radiobiology experiments at the TOP-IMPLART facility,” Biophysics and Bioengineering Letters, vol. 8, no. 1, May 2015.
    Retrieved from: http://ojs.uniroma1.it/index.php/CISB-BBL/article/view/13287/13086
    Retrieved on: Aug. 5, 2017
  15. M. Vadrucci et al., “Mimicking extreme astrophysical environments: first trials of irradiation of plant tissues with the TOP-IMPLART protontherapy accelerator,” presented at the Agrospace 2016 Conferenece, Sperlonga, Italy, 2016
  16. M. Vadrucci et al., “Diagnostics methods for the medium energy proton beam extracted by the TOP IMPLART linear accelerator,” in Proc. IPAC 2017, Copenhagen, Denmark, 2017, pp. 4673 – 4675
    Retrieved from: http://accelconf.web.cern.ch/AccelConf/ipac2017/papers/thpva091.pdf
    Retrieved on: Aug. 5, 2017
  17. E. Cisbani et al., “Micro pattern ionization chamber with adaptive amplifiers as dose delivery monitor for therapeutic proton LINAC,” in Proc. IBIC 2016, Barcelona, Spain, 2016, pp. 464 – 467
    Retrieved from: http://accelconf.web.cern.ch/AccelConf/ibic2016/papers/tupg51.pdf
    Retrieved on: Aug. 5, 2017
  18. C. De Angelis et al., “Characterization of a 27 MeV proton beam linear accelerator,” to be published in Proc. NEUDOS 2017, Kraków, Poland, 2017
  19. M. D. Falco et al., “Characterization of a cable-free system based on p-type MOSFET detectors for “in vivo” entrance skin dose measurements in interventional radiology,” Med Phys, vol. 39, no. 8, pp. 4866 – 4874, Jul. 2012.
    DOI: 10.1118/1.4736806
    PMid: 22894413
  20. M. Vadrucci et al., “Calibration of GafChromic EBT3 for absorbed dose measurements in 5 MeV proton beam and 60Co γ-rays,” Med. Phys., vol. 42, no. 8, pp. 4678–84, Aug. 2015.
    DOI: 10.1118/1.4926558
    PMid: 26233195
  21. ENEA-COBRA project, Development and dissemination of methods, advanced technologies and tools for the conservation of cultural heritage, based on application of radiation, ENEA, Rome, Italy
    Retrieved from: http://cobra.enea.it/english
    Retrieved on: Jul. 10, 2017
  22. M. Vadrucci et al, “Proton irradiations of micro-tom red hairy roots to mimic space conditions,” in Proc. IPAC2015, Richmond (VA), USA, 2015,pp. 2249 – 2252
    Retrieved from: http://accelconf.web.cern.ch/AccelConf/IPAC2015/papers/tupwi005.pdf
    Retrieved from: Aug. 5, 2017
  23. S. Massa et al., “Tomato hairy root cultures as a platform for the bioproduction of valuable molecules and as a tool to test extreme astrophysical conditions,” presented at the Agrospace 2016 Conferenece, Sperlonga, Italy, 2016